Lupus nephritis trials end in disappointment
نویسندگان
چکیده
منابع مشابه
Human clinical trials in lupus nephritis.
Improved patient survival after treatment of lupus nephritis with corticosteroids, immunosuppressants, and renal replacement therapy allows greater emphasis on long-term management issues. In particular, the recent focus has been on therapies to treat nephritis with fewer adverse effects compared with cyclophosphamide and immunosuppressive regimens. Issues complicating clinical trial design in ...
متن کاملLupus nephritis and end-stage kidney disease.
Systemic lupus erythematosus (SLE) is a multisystem disease affecting many organs. Varying degrees of renal involvement are seen in up to 60% of adults with SLE, and severe lupus nephritis (LN) (World Health Organization class III and above) progresses to end-stage kidney disease (ESKD) within 15 years of diagnosis in 10% to 30% of patients. In fact, renal injury is the most important predictor...
متن کاملThe prognosis of lupus nephritis in children
Introduction: Lupus nephritis is a systemic disease which affects different organs. The present study was designed to review lupus nephritis, in children its outcome and the related factors. Methods: We reviewed 48 children with lupus nephritis. Clinical and epidemiological features were studied. The patients’ outcomes and related factors were analyzed. Patient and renal survival rate were ca...
متن کاملTreatment of lupus nephritis: a meta-analysis of clinical trials.
The best therapeutic choice in lupus nephritis remains shrouded in a body of controversial literature. The purpose of this review was to assess and compare by meta-analysis the efficacy of therapeutic agents used in the treatment of lupus nephritis using outcomes of end-stage renal disease (ESRD) and total mortality. An exhaustive search was performed using MEDLINE (1970 to 1995) and manual sea...
متن کاملChemokines in lupus nephritis.
Lupus nephritis is a common solid organ manifestation of systemic lupus erythematosus (SLE). The disease is tightly linked to the production of autoantibodies and circulating immune complexes, i.e. immune complex glomerulonephritis. In this process chemokines mediate multiple biological effects, e.g. orchestrating proinflammatory microenvironments, the recruitment of immune cell subsets into th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2009
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2009.64